RESEARCH & STUDIES


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WHAT IS HYDROGEN WATER?

Hydrogen water is regular water infused with molecular hydrogen (H2).

Wait doesn't water already have hydrogen in it?

Yes and no.

Water or H2O is two parts hydrogen and one part oxygen covalently bonded together. So yes it contains a form of hydrogen.

But to unlock the benefits of molecular hydrogen you must separate the oxygen and hydrogen so the hydrogen atoms are free to exert their antioxidant properties.

Using the electrolysis process you can split these two elements.

The hydrogen absorbs into the water. The oxygen escapes out of vents on the base of the bottle.

HOW DOES MOLECULAR HYDROGEN WORK?

For most of medical history we thought hydrogen was just another inert gas with no real medical applications. All of that changed in 2007, when a group of researchers published their findings in the medical journal Nature showing that hydrogen is actually a unique and highly-effective antioxidant in the human body.

Since then, there have been over 1400 peer-reviewed studies showing that molecular hydrogen has therapeutic applications for over 170 different disease models.

HOW CAN THERE BE SO MANY APPLICATIONS?

It has a lot to do with something called oxidative stress. In a nutshell, oxidative stress is a damaging process that occurs when the body has too many free radicals and not enough antioxidants to keep them in check.

Oxidative stress causes the breakdown of cell tissue, DNA damage and increased inflammation.

These factors can effect any cell in the body and can cause an endless range of health issues such as:

  • Cancer
  • neurological diseases eg parkinsons & Alzheimer’s disease
  • Cardiovascular Disease
  • Diabetes
  • Memory loss
  • Ageing

Molecular hydrogen (H2) is an antioxidant that reduces oxidative stress by selectively targeting only harmful free radicals. So it makes sense that H2 has so many applications to prevent and fight a wide range of diseases within the body.

Webmd.com/What is oxidative stress ?What is oxidative stress ?

WHAT ARE FREE RADICALS?

Free radicals are molecules that have a single unpaired electron in their outer shell. Electrons don’t like being unpaired. This causes free radicals to react with other molecules to steal their electrons in order to stabilise, this damages healthy cells, mitochondria, proteins and DNA in the process.

Throughout our entire lives, our bodies are bombarded by harmful free radicals.

They often come from various environmental sources, such as

  • Air pollution
  • Heavy metal contamination
  • Pesticide use
  • Tobacco smoke
  • Alcohol
  • UV Exposure

However they are non-avoidable as they are also created internally through normal metabolic processes, exercise, injury, disease and inflammation.

They cause irreversible damage to the body, so preventative measures are preferred whenever possible.

WHAT ARE ANTIOXIDANTS?

Antioxidants are molecules stable enough to donate an electron to a cytotoxic free radical and neutralise them, thus reducing their capacity to cause a chain reaction of cellular damage.

Our bodies are able to produce natural antioxidants to combat these free radicals. However, as we age, our natural antioxidant production weakens.

When antioxidant production can’t keep up, and our bodys are exposed to harmful substances that produce free radicals they can start to wreak havoc on our bodies

In fact, the free radical theory of aging holds that damage from free radicals is the primary biochemical process that causes ageing.

Free radicals, antioxidants and functional foods: Impact on human health

WHY MOLECULAR HYDROGEN THE ULTIMATE ANTIOXIDANT

Multiple studies over the past decade have repeatedly supported the utility of molecular hydrogen as a powerful antioxidant. Hydrogen is an amazing antioxidant for a few reasons.

1. MOLECULAR HYDROGEN IS THE SMALLEST & PUREST ANTIOXIDANT THAT EXISTS.

H2 is far smaller than any other antioxidant, allowing it to easily enter deeper into our cells than all other Antioxidants. In fact, it is even small enough to penetrate the mitochondria of cells (the cell’s energy center, meaning H2 provides antioxidant protection at the source of harmful Free Radical production. Unlike other Antioxidants, H2 is also small enough to pass through the blood-brain barrier to provide protection against free radicals within the brain giving hydrogen water a range of neuroprotective effects.

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

2. MOLECULAR HYDROGEN IS THE "SMART" ANTIOXIDANT

Most Antioxidants have limited effectiveness for two reasons.

  • They can only protect against some free radicals but not others
  • They cannot distinguish between necessary & harmful Free Radicals.

some free radicals are beneficial to our cells, such as hydrogen peroxide. Molecular Hydrogen solves both problems. H2 selectively targets only the toxic oxygen radicals, and neutralizes every type of harmful free radical in our cells. H2 protects the cell’s DNA, RNA, protein, lipids & more from Oxidative Stress better than any other Antioxidant.

Hydrogen as a selective antioxidant

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

3. MOLECULAR HYDROGEN IS 100% NATURAL AND COMPLETELY SAFE.

H2 is absolutely safe because it is perfectly natural to the body. H2 requires no energy consumption to break down, has no known toxic effect at even high doses, and simply turns into water after providing its Antioxidant benefit. This is another major advantage of H2 over other types of Antioxidants. We can’t take an unlimited amount of other Antioxidants like vitamin C for example, since our bodies have to process it to break it down. Other Antioxidants have a toxic effect at high concentrations, but not H2.

Molecular hydrogen: a therapeutic antioxidant and beyond

4. MOLECULAR HYDROGEN IMPROVES THE BODY'S NATURAL ANTIOXIDANT SYSTEMS.

H2 also marshals the rest of the troops, and brings them to the fight. Because H2 is able to penetrate the nucleus, it has effects at the level of gene transcription, through activation of the NRF2 pathway This upregulates your body’s production of endogenous antioxidants, like glutathione, catalase and superoxide dismutase. This combination packs an extremely powerful antioxidant punch.

This is important to combat the general damage that reactive oxygen species (ROS) can cause, and has particular implications for longevity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412697/?ref=WENDI

reducing oxidative stress via the NrF2 pathway

HYDROGENS EFFECTS ON VARIOUS HEALTH ISSUES

As stated earlier hydrogen has the ability to provide treatment and preventative care for over 170 different dissease models by mitigating oxidative stress. Below is how hydrogen effects some of the most important health issues

Cognitive Function & Neurodegenerative Disorders 

Hydrogen water has shown impressive potential in treating and protecting against neurodegenerative disorders such as Parkinson's and Alzheimer's.

The antioxidant and anti inflammatory properties of molecular hydrogen prevents and treats inflammation of the brains neurons. Inflammation of these neurons can eventually lead to their death and degeneration of the brain. Hydrogen is one of the only antioxidants small enough to pass through the blood-brain barrier allowing it to exert its antioxidant effects within the brain. Reduced inflammation of the brain also leads to improved memory and mood.

Molecular hydrogen therapy for neurological diseases: a review of current evidence

Hydrogen-rich water ameliorates neuropathological impairments

The role of hydrogen therapy in Alzheimer's disease management

Athletic Performance

Hydrogen water can help reduce lactic acid accumulation and improve recovery times during and after workouts. Here's how it works:

  • Reduction of Oxidative Stress: Exercise induces oxidative stress, leading to the production of reactive oxygen species (ROS) which can contribute to muscle fatigue and soreness. Hydrogen water acts as an antioxidant, neutralizing these ROS and thereby reducing oxidative stress.

  • Mitigation of Lactic Acid Build-up: During intense exercise, the body produces lactic acid as a byproduct of anaerobic metabolism. High levels of lactic acid can lead to muscle fatigue and soreness. By reducing oxidative stress, hydrogen water can help maintain the balance of redox states in muscle cells, influencing the metabolic pathways involved in lactic acid production.

  • Anti-inflammatory Effects: Hydrogen water has anti-inflammatory properties, which can help reduce exercise-induced inflammation. This reduction in inflammation can contribute to less muscle soreness and quicker recovery times.

  • Enhanced Mitochondrial Function: Hydrogen water has been shown to improve mitochondrial function. Enhanced mitochondrial efficiency can lead to better energy production and utilization, thereby reducing the reliance on anaerobic metabolism and lowering lactic acid production.

Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training

Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study

Immunity

Hydrogen-rich water can support the immune system through several mechanisms, primarily due to its potent antioxidant and anti-inflammatory properties. Here’s how it helps:

  • Reduction of Oxidative Stress: Hydrogen-rich water acts as a selective antioxidant, neutralizing harmful reactive oxygen species (ROS) without affecting beneficial ROS involved in cell signaling. By reducing oxidative stress, it helps maintain the integrity and function of immune cells, which are particularly susceptible to oxidative damage.

  • Anti-inflammatory Effects: Chronic inflammation can impair immune function and lead to various diseases. Hydrogen-rich water can reduce inflammation by inhibiting pro-inflammatory cytokines and pathways, thus supporting a balanced immune response.

  • Modulation of Immune Cell Activity: Studies have shown that hydrogen-rich water can influence the activity of various immune cells, such as T cells, B cells, and macrophages. It can enhance the activity of T cells and promote the production of cytokines that are essential for an effective immune response.

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Energy levels

Hydrogen water can boost natural energy levels through several mechanisms

  • Enhanced Mitochondrial Function: Hydrogen water has been shown to improve mitochondrial efficiency. Mitochondria are the powerhouses of cells, responsible for producing ATP (adenosine triphosphate), which is the primary energy currency in the body. By enhancing mitochondrial function, hydrogen water can increase the production of ATP, leading to higher energy levels.

  • Reduction of Oxidative Stress: Hydrogen acts as a selective antioxidant, neutralising harmful reactive oxygen species (ROS) without affecting beneficial ROS involved in cellular signalling. By reducing oxidative stress, hydrogen water helps protect cells from damage and maintains their function, which contributes to sustained energy levels.

Hydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System

Hydrogen Water Drinking Exerts Antifatigue Effects

Can Hydrogen-rich water help in boosting energy and stamina?

Cancer

Hydrogen water has shown potential in preventing cancer and aiding in the treatment of cancer patients through several mechanisms

Prevention:

  • Reduction of Oxidative Stress: Oxidative stress caused by reactive oxygen species (ROS) is a significant factor in the development of cancer. Hydrogen water acts as a potent antioxidant, neutralizing ROS and reducing oxidative stress, thereby lowering the risk of DNA damage from free radicals (ROS) that can lead to cancer.

  • Anti-inflammatory Effects: Chronic inflammation is closely linked to the initiation and progression of cancer. By reducing inflammation, hydrogen water can decrease the likelihood of chronic inflammatory conditions that can predispose individuals to cancer.

Treatment:

  • Protecting Normal Cells During Chemotherapy and Radiation: Cancer treatments like chemotherapy and radiation therapy produce a significant amount of oxidative stress, which can damage normal cells along with cancer cells. Hydrogen water's antioxidant properties can help protect healthy cells from this oxidative damage without reducing the efficacy of cancer treatments.

  • Enhancing Chemotherapy and Radiation Tolerance: By reducing the side effects associated with oxidative stress and inflammation, hydrogen water can improve patients' tolerance to chemotherapy and radiation, potentially allowing for more aggressive or prolonged treatment regimens.

  • Improving Quality of Life: Cancer treatments often come with severe side effects, including fatigue, nausea, and cognitive impairment. Hydrogen water has been shown to reduce these side effects, improving the overall quality of life for cancer patients.

  • Inhibiting Cancer Cell Growth: Some studies suggest that hydrogen water might have direct anti-cancer effects. For instance, research indicates that hydrogen can inhibit the proliferation of cancer cells and induce apoptosis (programmed cell death) in certain cancer cell lines.

Prospects of molecular hydrogen in cancer prevention and treatment

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

“Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients

Ageing & Skin Apperance

Prevention of Aging:

  • Reduction of Oxidative Stress: Oxidative stress is a significant contributor to aging, causing damage to cells, proteins, and DNA. Hydrogen water acts as a potent antioxidant, neutralizing harmful free radicals and reducing oxidative stress throughout the body, including the skin.

  • Protection Against UV Damage: Exposure to ultraviolet (UV) radiation from the sun can accelerate skin aging by inducing oxidative stress and inflammation. Hydrogen water's antioxidant properties may help protect the skin from UV-induced damage, reducing the risk of premature aging and skin cancer.

  • Promotion of DNA Repair: Hydrogen water enhances the body's ability to repair DNA damage caused by oxidative stress. By promoting DNA repair mechanisms, hydrogen water can help maintain the integrity of skin cells and delay the onset of aging-related changes.

Improvement of Skin Health:

  • Hydration: Proper hydration is essential for maintaining healthy skin. Hydrogen-rich water is more easily absorbed at the cellular level, providing better hydration and moisture retention for the skin. This can result in improved skin elasticity, suppleness, and a more youthful appearance.

  • Reduction of Inflammation: Chronic inflammation can contribute to various skin conditions, including acne, eczema, and psoriasis. Hydrogen water's anti-inflammatory properties help reduce inflammation in the skin, soothing irritation and redness and promoting a clearer complexion.

  • Enhancement of Collagen Production: Collagen is a protein that provides structural support to the skin, keeping it firm and resilient. Hydrogen water has been suggested to stimulate collagen production, helping to maintain skin elasticity and reduce the appearance of wrinkles and fine lines.

Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Cardio Vascular Issues

Hydrogen water has shown promise in treating cardiovascular disease through several mechanisms

  • Reduction of Oxidative Stress: Oxidative stress plays a critical role in the development and progression of cardiovascular diseases such as atherosclerosis, hypertension, and heart failure. Hydrogen water acts as a potent antioxidant, scavenging harmful free radicals and reducing oxidative damage to blood vessels and cardiac tissues.

  • Improvement of Endothelial Function: The endothelium, the inner lining of blood vessels, plays a crucial role in regulating vascular tone, inflammation, and blood clotting. Hydrogen water has been shown to improve endothelial function by enhancing nitric oxide production, promoting vasodilation, and reducing inflammation, thus supporting overall cardiovascular health.

  • Lowering Blood Pressure: Hydrogen water may help lower blood pressure by promoting vasodilation and reducing arterial stiffness. Several studies have demonstrated the antihypertensive effects of hydrogen

  • Reducing Cholesterol Levels: High levels of cholesterol, particularly LDL (low-density lipoprotein) cholesterol, are a significant risk factor for cardiovascular disease. Hydrogen water has been shown to reduce LDL cholesterol levels and increase HDL (high-density lipoprotein) cholesterol levels, contributing to a healthier lipid profile and reducing the risk of atherosclerosis.

  • Protection Against Ischemia-Reperfusion Injury: Ischemia-reperfusion injury occurs when blood flow is restored to tissues after a period of ischemia (lack of blood supply), leading to oxidative stress and inflammation. Hydrogen water has been found to mitigate ischemia-reperfusion injury in various organs, including the heart, by reducing oxidative damage and inflammation, thus protecting against myocardial infarction and other cardiac events.

Hydrogen therapy as a potential therapeutic intervention in heart disease:

A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

Gut Health

Hydrogen water can improve gut health through several mechanisms,

  • Reduction of Oxidative Stress: The gut is frequently exposed to oxidative stress from various sources, including diet, pathogens, and inflammation. Hydrogen water acts as a potent antioxidant, neutralizing reactive oxygen species (ROS) and reducing oxidative stress in the gastrointestinal tract. This protection helps maintain the integrity of the gut lining and prevents damage to the cells of the digestive tract.

  • Anti-inflammatory Effects: Chronic inflammation in the gut is associated with various gastrointestinal disorders such as inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Hydrogen water's anti-inflammatory properties can help reduce inflammation in the gut, alleviating symptoms and promoting healing of the intestinal lining.

  • Modulation of Gut Microbiota: A balanced gut microbiota is essential for overall gut health. Hydrogen water has been shown to positively influence the composition of gut microbiota, promoting the growth of beneficial bacteria while suppressing harmful ones.

  • Alleviation of Gastrointestinal Symptoms: By reducing oxidative stress and inflammation, hydrogen water can help alleviate various gastrointestinal symptoms such as bloating, diarrhea, and constipation. This can improve overall digestive comfort and function.

Hydrogen-Rich Water Using as a Modulator of Gut Microbiota and Managing the Inflammatory Bowel Disease

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice

Diabetes

Hydrogen water has shown potential in helping manage diabetes through several mechanisms

  • Reduction of Oxidative Stress: Diabetes is associated with increased oxidative stress, which contributes to insulin resistance and pancreatic beta-cell dysfunction. Hydrogen water acts as a potent antioxidant, neutralizing reactive oxygen species (ROS) and reducing oxidative damage in tissues, including the pancreas and muscles. This helps preserve insulin function and improve glucose metabolism.

  • Improvement of Insulin Sensitivity: Insulin resistance is a hallmark of type 2 diabetes. By reducing oxidative stress and inflammation, hydrogen water can enhance the responsiveness of cells to insulin, thereby improving insulin sensitivity and facilitating better glucose uptake by cells.

  • Protection of Pancreatic Beta Cells: In both type 1 and type 2 diabetes, the pancreatic beta cells that produce insulin can be damaged by oxidative stress and inflammation. Hydrogen water can protect these cells from damage, preserving their function and aiding in the regulation of blood glucose levels.

  • Improvement of Lipid Metabolism: Dyslipidemia (abnormal lipid levels) often accompanies diabetes and contributes to cardiovascular complications. Hydrogen water has been shown to improve lipid profiles by reducing levels of triglycerides and LDL (bad) cholesterol while increasing HDL (good) cholesterol.

  • Enhancement of Glucose Metabolism: Hydrogen water can enhance glucose metabolism by activating pathways involved in energy production and glucose utilization, helping to maintain normal blood glucose levels.

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

Hydrogen Water – Reduce Risk of Type 2 Diabetes with Simple Change

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